Practice Questions

20. The interaction between high-density lipoproteins (HDL) and peripheral tissue cells is medically beneficial because HDL

A. Deposits cholesterol into arterial walls
B. Transports excess cholesterol back to the liver for excretion
C. Synthesizes novel fatty acid chains from glucose
D. Stores triacylglycerols inside adipocytes

HDL participates in reverse cholesterol transport, clearing excess lipids from blood vessels and carrying them back to the hepatic tissue.

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19. The structural distinction between a glycoprotein and a proteoglycan is that a proteoglycan contains

A. More lipid than carbohydrate
B. A higher percentage of carbohydrate, primarily composed of long glycosaminoglycan chains
C. No covalent bonds between its parts
D. An exclusively intranuclear function

Proteoglycans are mostly carbohydrate by weight (80%–95%), containing long unbranched GAG chains, unlike standard glycoproteins.

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18. A genetic defect that prevents the addition of mannose-6-phosphate to targeted glycoproteins in the Golgi apparatus will disrupt the

A. Synthesis of ATP in mitochondria
B. Delivery of structural enzymes to lysosomes
C. Replication of nuclear DNA sequences
D. Secretion of insulin into the blood

Mannose-6-phosphate serves as a specific molecular sorting signal that targets newly synthesized hydrolytic enzymes to the lysosomes.

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Jul 3, 2026

17. An analysis of a patient’s blood type reveals the presence of specific A-antigens on the erythrocyte surface, which chemically are

A. Pure structural proteins
B. Specific oligosaccharide chains attached to lipids or proteins
C. Long linear homopolysaccharides
D. Extracellular DNA-protein loops

Human ABO blood group determinants are defined by the structural variations of carbohydrate chains on surface glycolipids and glycoproteins.

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16. The cell coat, or glycocalyx, which plays an essential role in tissue transplantation rejection and cell-to-cell recognition, is composed of

A. Phospholipids and cholesterol
B. Glycoproteins and glycolipids
C. Nucleic acids and histones
D. Actin filaments and myosin

The glycocalyx acts as a cellular fingerprint; individual combinations of sugar chains allow immune cells to distinguish self from non-self.

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15. The presence of oligosaccharide side chains on a membrane protein generally makes that specific region of the molecule

A. Highly hydrophobic
B. Highly hydrophilic
C. Chemically unreactive
D. Completely insoluble in water

Hydroxyl groups on sugar residues form hydrogen bonds with surrounding water molecules, rendering the region highly hydrophilic.

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Jul 3, 2026

14. The chemical nature of the prosthetic group in a lipopolysaccharide molecule found in bacterial outer membranes is a

A. Amino acid sequence
B. Lipid component
C. Nucleotide polymer
D. Mineral crystal

Lipopolysaccharides (LPS) contain a lipid A anchor component covalently bound to a core oligosaccharide and an O-antigen chain.

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Mucus contains mucins, which are heavily glycosylated glycoproteins that trap pathogens and protect delicate mucosal surfaces.

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Ribosomes are functional structural complexes consisting of ribosomal RNA (rRNA) and specific ribosomal proteins working together.

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Hemoglobin is a metalloprotein containing an iron-porphyrin ring system called a heme group as its functional prosthetic group.

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